My research interest is in reducing disease burden, improving diagnostics and treatment of HIV-associated infections through epidemiology, laboratory technologies and clinical trials. My major disease areas of interest are HIV-associated opportunistic infections, specifically Penicillium marneffei infection, HIV drug resistance, and HIV-HCV coinfection. I collaborate closely with major hospitals providing HIV care throughout Vietnam. Currently I am the Principal Investigator of 2 ongoing multi-center clinical trials, one comparing amphotericin B and itraconazole in the treatment of HIV-associated penicilliosis, the other to evaluate the safety of raltegravir compared to efavirenz in HIV-HCV coinfection. I also lead and collaborate on studies to understand disease epidemiology, identifying risk factors for infections, and improving diagnostics and treatment of penicilliosis.
Clinical features of three patients with paradoxical immune reconstitution inflammatory syndrome associated with Talaromyces marneffei infection.
Thanh NT. et al, (2018), Med Mycol Case Rep, 19, 33 - 37
Fungal infections in HIV/AIDS.
Limper AH. et al, (2017), Lancet Infect Dis, 17, e334 - e343
Itraconazole and antiretroviral therapy: strategies for empirical dosing - Author's reply.
Le T. et al, (2017), Lancet Infect Dis, 17, 1123 - 1124
Itraconazole or Amphotericin B for Talaromycosis.
Le T. et al, (2017), N Engl J Med, 377
New diagnostic tools in endemic mycoses
Le T. and Pasqualotto AC., (2017), MYCOSES, 60, 14 - 14