Ellie (Eleanor) Barnes
Professor of Hepatology and Experimental Medicine
I lead an established research group with a focus on T cell immunology relevant to gut and liver disease, and I seek to translate laboratory and clinical findings through to human experimental medicine studies.
My group is developing pan-genotypic vaccines for HCV prevention and HBV cure using simian adenoviral and other viral vectors. A major challenge for HCV vaccine development is the significant viral diversity both within the same host and between hosts –though parts of the viral genome are conserved making these excellent T cell targets in the context of a T cell vaccine. Some of the technologies we are developing include integral genetic adjuvants that will have applicability in a broad range of diseases. We are also establishing a new rat model of HCV infection that will also us to evaluate vaccine candidates at an early stage.
More recently my group is developing national programs in stratified medicine; I lead STOP-HCV, an MRC funded stratified medicine national consortium (22 partners) that unites clinicians, scientists and industry partners in studies of personalised medicine integrating viral and host genetics with immune and other biomarker parameters (STOP-HCV.ox.ac.uk/home). We have established new pathogen sequencing technologies and are particularly interested in how host genomes affect microbial diversity, and have a portfolio of stratified medicine studies that have recently extended to S.E. Asia.
I lead additional programs of work in immune mediated liver disease. One of these, IgG4-related disease (of unknown aetiology, only very recently described) affects multiple organs and includes severe biliary and pancreatic pathology, characterised by a lymphocytic infiltrate with IgG4 producing B cells. We have now established a large cohort of patients and a national registry (funded through EASL) and are currently performing detailed assessment of T and B cells profiles to further define pathogenesis.
My group is developing liver imaging techniques with OCMR for the non-invasive detection of organ fibrosis and inflammation.
As NIHR CLRN lead for hepatology in the Thames Valley I oversee a portfolio of clinical studies relating to gastroenterology and hepatology at the Oxford University NHS Trust, Oxford.
The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam
McCabe L. et al, (2020), Trials, 21
Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1.
Innes H. et al, (2020), Gastroenterology
Viral vectored hepatitis C virus vaccines generate pan-genotypic T cell responses to conserved subdominant epitopes.
Donnison T. et al, (2020), Vaccine
MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans.
Esposito I. et al, (2020), Science translational medicine, 12
High Mortality Rates for SARS-CoV-2 Infection in Patients with Pre-existing Chronic Liver Disease and Cirrhosis: Preliminary Results from an International Registry.
Moon AM. et al, (2020), Journal of Hepatology