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Leveraging genetics to help inform drug target discovery

Research

A new study led by Professor Julian Knight at the Wellcome Centre for Human Genetics and colleagues from the ULTRA-DD Consortium shows how genetics and knowledge of networks can prioritise drug targets for immune-mediated diseases.

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

Research

Researchers from the University of Oxford, including NDM's Professor Simon Draper, along with partners from five institutions around the world, have identified the human antibodies that prevent the malaria parasite from entering blood cells, which may be key to creating a highly effective malaria vaccination.

Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV)

Research

Hepatitis B virus (HBV) infects 290 million people worldwide. Oxford Nanopore Technology sequencing platforms provide potential for sequencing the whole HBV genome in a single read, facilitating improved insights into virus epidemiology, diversity, and pathogenesis.

A Novel Vaccine Strategy Employing Serologically Different Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection

Research

Nearly 3 million people are co-infected with hepatitis C and HIV. Effective preventive strategies targeting both viruses are needed.

Assessment of Immunogenicity and Neutralisation Efficacy of Viral-Vectored Vaccines Against Chikungunya Virus

Research

Chikungunya virus (CHIKV) has caused explosive outbreaks in more than 60 countries. Infection can cause a long-term, debilitating disease characterised by joint inflammation and chronic arthritis lasting several years.

Research identifies how the gut loses protective barrier function in IBD

Research

A research team led by Prof Alison Simmons at MRC HIU and Professor of Gastroenterology used single-cell technology to identify new players in the gut epithelial barrier.

A new role for Zinc in immune function

Research

A new study by the Cornall group provides new insights into the importance of zinc in human health.

Venous identity requires BMP signalling through ALK3

Research

Ludwig Institute's study of venous development by Professor Sarah De Val, identifying a new potential target for anti-angiogenic cancer therapy is now published in Nature Communications.

Designer protein delivers signal of choice

Research

A computational strategy has delivered a redesigned, more stable version of a cytokine protein that mimics the natural protein’s interactions with receptors, opening the way for designer cytokine-based therapeutics.

The double burden of diabetes and global infection in low and middle-income countries

Research

Four out of five people in the world with diabetes now live in low and middle income countries.

Safety and immunogenicity of a heterologous prime-boost Ebola virus vaccine regimen - ChAd3-EBO-Z followed by MVA-EBO-Z in healthy adults in the UK and Senegal

Research

Vaccines against Ebola remain an urgent global health priority and outbreaks continue, notably the ongoing outbreak in North Kivu in the DRC.

Structural study of antibiotic opens the way for new TB treatments

Research

New analysis of the structure and function of the naturally-occurring antimicrobial agent tunicamycin has revealed ways to produce new, safe antibiotics for Mycobacterium tuberculosis and other disease-causing bacteria.

Intragenic transcriptional interference regulates the human immune ligand MICA.

Research

Disease processes can switch genes on or off in a cell and this can alter the progress of the disease.

Trends in the Incidence and Recurrence of Inpatient-Treated Spontaneous Pneumothorax, 1968-2016

Research

Pneumothorax is a common condition which can affect anyone where air leaks from the lung and causes lung collapse.

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

Research

Ross Chapman and WTCHG colleagues have published their research in Nature which describes the discovery of the Shieldin complex, a single-stranded DNA-binding repair complex that is essential for context-dependent DNA repair events in the immune system and cancer.

Addressing challenges faced by insecticide spraying for the control of dengue fever in Bangkok, Thailand: a qualitative approach

Research

A study from Bangkok by Professor Wirichada Pan-Ngum and colleagues shows accessing households for proper spraying was a problem for control dengue outbreaks.

Development of a highly protective Zika vaccine through modulation of antigen membrane anchors

Research

The leading Oxford’s chimpanzee adenovirus vaccine platform has been engineered as a Zika vaccine, opening the door to clinical trials at the University of Oxford and Mexico.

Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis

Research

The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified.

A global map of travel time to cities to assess inequalities in accessibility in 2015

Research

The Malaria Atlas Project has created a global map of the travel time to urban centers for the year 2015. Cities concentrate activities that promote human wellbeing including education, employment, and healthcare services.

Scrub Typhus Point-of-Care Testing

Research

Kartika Karaswati, Stuart Blacksell and colleagues reviewed the diagnostic accuracy of the available scrub typhus point-of-care tests, feasible to be used in resource limited settings.

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