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Emerging tools to investigate bromodomain functions

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Kougnassoukou Tchara P-E. et al, (2020), Methods, 184, 40 - 52

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Louphrasitthiphol P. et al, (2020), Molecular Cell, 79, 472 - 487.e10

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells

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Lines KE. et al, (2020), Endocrine-Related Cancer, 27, 163 - 174

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

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Hassell-Hart S. et al, (2020), ORGANOMETALLICS, 39, 408 - 416

A chemical toolbox for the study of bromodomains and epigenetic signaling

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Wu Q. et al, (2019), Nature Communications, 10

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Journal article

Chen Z. et al, (2019), Structure, 27, 1395 - 1404.e4

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

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Marabelli C. et al, (2019), Cell Reports, 27, 387 - 399.e7

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

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Ivanochko D. et al, (2019), Nucleic Acids Research, 47, 1225 - 1238

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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Lambert J-P. et al, (2019), Molecular Cell, 73, 621 - 638.e17

Evaluation of linker length effects on a BET bromodomain probe

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Traquete R. et al, (2019), Chemical Communications, 55, 10128 - 10131

A TFEB nuclear export signal integrates amino acid supply and glucose availability

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Li L. et al, (2018), Nature Communications, 9

What Is the BET on Solid Tumors?

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Filippakopoulos P., (2018), Journal of Clinical Oncology, 36, 3040 - 3042

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

Journal article

Ngeow KC. et al, (2018), Proceedings of the National Academy of Sciences, 115

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling

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Hrdinka M. et al, (2018), The EMBO Journal, 37

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells

Journal article

Shiota H. et al, (2018), Cell Reports, 24, 3477 - 3487.e6

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

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Jennings LE. et al, (2018), Bioorganic & Medicinal Chemistry, 26, 2937 - 2957

The C-terminal extension landscape of naturally presented HLA-I ligands

Journal article

Guillaume P. et al, (2018), Proceedings of the National Academy of Sciences, 115, 5083 - 5088

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