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Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Journal article

Raux B. et al, (2024), Bioorganic & medicinal chemistry letters, 98

Open resources for chemical probes and their implications for future drug discovery

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Balıkçı E. et al, (2023), Expert Opinion on Drug Discovery, 1 - 9

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Journal article

Londregan AT. et al, (2023), Journal of medicinal chemistry, 66, 460 - 472

Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes.

Journal article

Rothweiler EM. and Huber KVM., (2023), Methods in molecular biology (Clifton, N.J.), 2706, 191 - 200

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation.

Journal article

Ketley RF. et al, (2022), Cell reports, 41

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Journal article

Rothweiler EM. et al, (2022), Biological Chemistry, 403, 391 - 402

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

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Martin JG. et al, (2021), ChemBioChem, 22, 2116 - 2123

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

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Mackinnon SR. et al, (2021), ACS Chemical Biology, 16, 586 - 595

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

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Pinto-Fernandez A. et al, (2021), British Journal of Cancer, 124, 817 - 830

Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

Journal article

Álvarez-Coiradas E. et al, (2020), International immunopharmacology, 89

Quantifying CDK inhibitor selectivity in live cells.

Journal article

Wells CI. et al, (2020), Nature communications, 11

Quantifying Target Occupancy of Small Molecules Within Living Cells.

Journal article

Robers MB. et al, (2020), Annual review of biochemistry

Importance of Quantifying Drug-Target Engagement in Cells

Journal article

Stefaniak J. and Huber KVM., (2020), ACS Medicinal Chemistry Letters

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