Structural Analysis and Development of Notum Fragment Screening Hits.
Journal article
Zhao Y. et al, (2022), ACS chemical neuroscience
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.
Journal article
Jackson V. et al, (2022), Structure (London, England : 1993)
Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
Journal article
Walters LC. et al, (2022), Cell reports, 39
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Journal article
Willis NJ. et al, (2022), Journal of medicinal chemistry
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
Journal article
Li D. et al, (2022), Commun Biol, 5
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Quantitative SARS-CoV-2 anti-spike responses to Pfizer–BioNTech and Oxford–AstraZeneca vaccines by previous infection status
Journal article
Eyre DW. et al, (2021), Clinical Microbiology and Infection, 27, 1516.e7 - 1516.e14
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Journal article
Flanagan DJ. et al, (2021), Nature
Small-molecule inhibitors of carboxylesterase Notum
Journal article
Zhao Y. et al, (2021), Future Medicinal Chemistry
Notum Deacylates Octanoylated Ghrelin
Journal article
Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
Journal article
Schwerd T. et al, (2020), Bone Research, 8
Caffeine inhibits Notum activity by binding at the catalytic pocket
Journal article
Zhao Y. et al, (2020), Communications Biology, 3
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Journal article
Zhao Y. et al, (2020), Nature Communications, 11
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Journal article
Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5
The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs
Journal article
Jackson V. et al, (2020)
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Journal article
Mahy W. et al, (2020), Journal of medicinal chemistry
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Journal article
Schwerd T. et al, (2020), Bone research, 8
Structural basis of semaphorin‐plexin cis interaction
Journal article
Rozbesky D. et al, (2020), The EMBO Journal
Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Journal article
Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260
Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility.
Journal article
Rozbesky D. et al, (2020), Structure (London, England : 1993)