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Mammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non-living mucosal vaccines and immunostimulators.

Original publication

DOI

10.1098/rstb.2000.0610

Type

Journal article

Journal

Philos Trans R Soc Lond B Biol Sci

Publication Date

29/05/2000

Volume

355

Pages

705 - 712

Keywords

Adjuvants, Immunologic, Animals, Anti-Bacterial Agents, Antigens, Bacterial, Bacterial Vaccines, Citrobacter, Disease Models, Animal, Enterobacteriaceae Infections, Enterotoxins, Humans, Immunity, Mucosal, Mice, Mucous Membrane