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A case of meningococcal septicaemia is reported in an adult with a deficiency of the seventh component of complement combined with a deficiency of the B locus product of C4. A family study demonstrated that the two deficiencies were not linked. This is the first time that the individual alleles of C4 were determined in a patient with a deficiency of one component of the terminal pathway. It is possible that the heterogeneous clinical picture of a terminal pathway deficiency may, in part, be explained by the co-existence of other subtle complement defects.

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

01/1987

Volume

67

Pages

55 - 58

Keywords

Adult, Complement C4, Complement C4b, Complement C7, Humans, Male, Meningococcal Infections, Pedigree