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We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

Original publication

DOI

10.1086/342299

Type

Journal article

Journal

Clin Infect Dis

Publication Date

15/09/2002

Volume

35

Pages

769 - 772

Keywords

Acetazolamide, Acidosis, Administration, Oral, Adult, Amphotericin B, Antifungal Agents, Diuretics, Double-Blind Method, Female, Headache, Humans, Hypokalemia, Intracranial Hypertension, Male, Meningitis, Cryptococcal, Middle Aged