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The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants on protease inhibitor-based ART (n=9), efavirenz-based ART (n=15), other ART (n=8), and those not on ART (n=31). Efavirenz appeared to inhibit chloroquine desethylation.

Original publication

DOI

10.1093/cid/ciy405

Type

Journal article

Journal

Clin Infect Dis

Publication Date

16/05/2018