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The expression of cyclin-dependent kinase inhibitor p27(kip1) in human tumors and normal tissues was investigated using a panel of novel anti-p27(kip1) mAbs. An inverse correlation between expression of p27(kip1) and cell proliferation was generally observed after analyzing its expression in 25 different normal human tissues. In some highly proliferative human breast cancer cells, however, high level p27(kip1) expression was seen, indicating the existence of a mechanism by which some growing tumor cells may tolerate this inhibitor of cell cycle progression. Detailed studies demonstrated a correlation between the high level expression of p27(kip1) and cyclin D1 in human breast cancer cells. There was also an inverse correlation between the expression of p27(kip1) and the degree of tumor malignancy in human breast and colorectal cancers, indicating that p27(kip1) may be a useful prognostic marker in these cancers.

Original publication

DOI

10.1073/pnas.94.12.6380

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

10/06/1997

Volume

94

Pages

6380 - 6385

Keywords

Biomarkers, Tumor, Breast Neoplasms, Cell Cycle, Cell Cycle Proteins, Cell Division, Colorectal Neoplasms, Cyclin D1, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinases, Cyclins, Female, Genes, Tumor Suppressor, Humans, Immunohistochemistry, Kinetics, Male, Microtubule-Associated Proteins, Oncogene Proteins, Organ Specificity, Prognosis, Reference Values, Tumor Cells, Cultured, Tumor Suppressor Proteins