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Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates of Streptococcus pneumoniae from clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates. PCV13 serotypes accounted for 60% (95% confidence interval [CI] 52-67) of all isolates; 56% (95% CI 48-64) of noninvasive and 77% (95% CI 57-89) of invasive isolates. Antibiotic resistance was more common among PCV13 serotypes. This study of clinical S. pneumoniae isolates supports the potential for high reduction in pneumococcal disease burden and may serve as baseline data for future monitoring of S. pneumoniae serotypes circulation after implementation of PCV13 childhood vaccination in Cambodia.

Original publication

DOI

10.4269/ajtmh.17-0692

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

03/2018

Volume

98

Pages

791 - 796

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacterial Typing Techniques, Bronchoalveolar Lavage Fluid, Cambodia, Child, Child, Preschool, Drug Resistance, Multiple, Bacterial, Female, Humans, Infant, Laboratories, Hospital, Male, Mass Vaccination, Middle Aged, Pneumococcal Vaccines, Pneumonia, Pneumococcal, Serogroup, Sputum, Streptococcus pneumoniae, Vaccines, Conjugate