Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We describe here the sequence of the Plasmodium vivax mdr1 gene from 10 different isolates differing in chloroquine sensitivity. The deduced amino acid sequence of PvMDR1 shares more than 70% similarity with other malarial MDR proteins and it displays consensus motifs of an ABC family transporter including two transmembrane domains and two ATP binding cassettes. Similarity and dendrogram analyses revealed that sequences could be grouped according to their geographical origin. Within each geographical group however, no correlation was found between chloroquine resistance and specific mutations.

Original publication

DOI

10.1016/j.exppara.2004.12.005

Type

Journal article

Journal

Exp Parasitol

Publication Date

04/2005

Volume

109

Pages

256 - 259

Keywords

ATP Binding Cassette Transporter, Subfamily B, Member 1, Alleles, Amino Acid Sequence, Animals, Antimalarials, Brazil, Chloroquine, Consensus Sequence, Conserved Sequence, Drug Resistance, Genes, MDR, Genetic Variation, Haplorhini, Humans, Molecular Sequence Data, Papua New Guinea, Phylogeny, Plasmodium vivax, Point Mutation, Sequence Alignment