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Human lymphocytes stimulated in vitro by allogeneic small cell lung carcinoma cell lines did not show any significant cytolytic activity against the stimulator tumor cells. However, a high level of lysis was observed when both stimulator and target small cell lung carcinoma cells were pretreated with interferon gamma, which increased considerably the expression of major histocompatibility class I molecules by these cells. The demonstration that small cell lung carcinoma cells can be lysed by cytolytic T lymphocytes, suggests that it will be feasible to study the autologous T cell response of patients against this tumor.

Type

Journal article

Journal

Cancer Immunol Immunother

Publication Date

1988

Volume

27

Pages

228 - 232

Keywords

Carcinoma, Small Cell, Cytotoxicity, Immunologic, HLA Antigens, Humans, Interferon-gamma, Lung Neoplasms, T-Lymphocytes, Cytotoxic