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A series of tumor cell antigens that are recognized by cytolytic T lymphocytes has been characterized this year. Besides the antigens derived from proteins specifically expressed in tumors, many melanoma antigens derive from melanocytic differentiation proteins. In addition, antigens unique to individual tumors result from mutations in ubiquitously expressed genes.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/1995

Volume

7

Pages

674 - 681

Keywords

Amino Acid Sequence, Animals, Antigens, Differentiation, Antigens, Neoplasm, Biomarkers, Tumor, Humans, Melanoma, Melanoma, Experimental, Mice, Molecular Sequence Data, T-Lymphocytes