Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high-throughput technologies for the efficient structure determination of proteins of biomedical importance, such as those of bacterial and viral pathogens linked to human health. Despite the challenging nature of some of these targets, 175 novel pathogen protein structures (approximately 220 including complexes) have been determined to date. Here the impact of several technologies on the structural determination of proteins from human pathogens is illustrated with selected examples, including the parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens.

Original publication

DOI

10.1107/S0907444906030915

Type

Journal article

Journal

Acta Crystallogr D Biol Crystallogr

Publication Date

10/2006

Volume

62

Pages

1196 - 1207

Keywords

Animals, Bacterial Infections, Bacterial Proteins, Humans, Protein Folding, Proteomics, Viral Proteins, Virus Diseases