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Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently.

Original publication

DOI

10.1016/s0035-9203(03)90165-9

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

05/2003

Volume

97

Pages

343 - 344

Keywords

Acute Disease, Adolescent, Antimalarials, Child, Chloroquine, Drug Combinations, Humans, Malaria, Falciparum, Pyrimethamine, Single-Blind Method, Sulfadoxine, Treatment Failure