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A new class of human renin inhibitor is described, containing a novel analogue of the peptide bond. High inhibitory potency was observed for octapeptide-length substrate analogues but inhibition progressively weakened as the molecule was shortened from the amino terminal end.

Type

Journal article

Journal

Biochem Biophys Res Commun

Publication Date

14/01/1986

Volume

134

Pages

71 - 77

Keywords

Amino Acid Sequence, Angiotensinogen, Humans, Kinetics, Mathematics, Oligopeptides, Renin, Structure-Activity Relationship