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Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.

Original publication

DOI

10.1038/sj.bjc.6602454

Type

Journal article

Journal

Br J Cancer

Publication Date

28/03/2005

Volume

92

Pages

1126 - 1129

Keywords

Adaptor Proteins, Signal Transducing, Adaptor Proteins, Vesicular Transport, DNA Helicases, Humans, Introns, Mutation, Nuclear Proteins, Peutz-Jeghers Syndrome, Polymorphism, Genetic, Transcription Factors