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A clinical strain of Acinetobacter baumannii (strain Ab41) that was resistant to all beta-lactam antibiotics tested except ceftazidime, ceftriaxone, ceftizoxime, and imipenem produced three beta-lactamases: a presumptive chromosomal cephalosporinase, a TEM-1-like beta-lactamase (pI 5.4), and a novel OXA-derived beta-lactamase named OXA-21 (pI 7.0). The gene encoding OXA-21 was located in an integron. The nucleotide sequence showed three mutations compared with the sequence of OXA-3, with two being silent; the nonsilent mutation generated a substitution of Ile-217 to Met.

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

12/1997

Volume

41

Pages

2757 - 2759

Keywords

Acinetobacter, Amino Acid Sequence, Base Sequence, Cloning, Molecular, Isoelectric Focusing, Molecular Sequence Data, Sequence Analysis, DNA, beta-Lactamases