Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

Original publication

DOI

10.1038/35073658

Type

Journal article

Journal

Nature

Publication Date

19/04/2001

Volume

410

Pages

980 - 987

Keywords

AIDS Vaccines, Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cytotoxicity, Immunologic, HIV, HIV Infections, Humans, Immune Tolerance, Lymphocyte Activation, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer