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The west Africa Ebola virus disease (EVD) epidemic was extraordinary in scale. Now that the epidemic has ended, it is a relevant time to examine published studies with direct relevance to clinical care and, more broadly, to examine the implications of the clinical research response mounted. Clinically relevant research includes literature detailing risk factors for and clinical manifestations of EVD, laboratory and other investigation findings in patients, experimental vaccine and therapeutic clinical trials, and analyses of survivor syndrome. In this Review, we discuss new insights from patient-oriented research completed during the west Africa epidemic, identify ongoing knowledge gaps, and suggest priorities for future research.

Original publication

DOI

10.1016/S1473-3099(17)30234-7

Type

Journal article

Journal

Lancet Infect Dis

Publication Date

09/2017

Volume

17

Pages

e280 - e292

Keywords

Africa, Western, Biomedical Research, Epidemics, Hemorrhagic Fever, Ebola, Humans, Mortality, Time Factors