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AIM: To determine the potential for drug interactions involving cytochrome P450 (CYP) in patients receiving palliative day care. METHODS: Drugs used by patients attending four specialist palliative day care centres were reviewed to identify combinations that could result in a pharmacokinetic interaction via any of the five main human forms of CYP. RESULTS: Of 160 patients, 145 (91%) were prescribed at least one drug that was a substrate, inhibitor or inducer of one of the five main CYP isoforms. Twenty-four drug combinations, involving 34 patients, could have given rise to a clinically important interaction. CONCLUSIONS: Prescribers should be aware that in this group of patients, one in five are at risk of a clinically important CYP-mediated drug interaction.

Original publication

DOI

10.1111/j.1365-2125.2005.02428.x

Type

Journal article

Journal

Br J Clin Pharmacol

Publication Date

09/2005

Volume

60

Pages

326 - 329

Keywords

Adult, Aged, Aged, 80 and over, Cytochrome P-450 Enzyme System, Day Care, Medical, Drug Combinations, Drug Interactions, Female, Humans, Male, Middle Aged, Palliative Care