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Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

Original publication

DOI

10.1038/ng.381

Type

Journal article

Journal

Nat Genet

Publication Date

06/2009

Volume

41

Pages

703 - 707

Keywords

Algorithms, Antigens, CD, CTLA-4 Antigen, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, DEAD-box RNA Helicases, DNA, Diabetes Mellitus, Type 1, Family, Female, Genome-Wide Association Study, Genotype, HLA Antigens, Humans, Interferon-Induced Helicase, IFIH1, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Risk Assessment, Siblings