Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Pertussis toxin (PTX) is the primary component responsible for eliciting the majority of biological activities associated with Bordetella pertussis, including the induction of several tissue-adjuvant models of organ-specific autoimmune disease. PTX, when administered in vivo, enhances vascular permeability, which is made manifest by a concomitant increase in sensitivity to a variety of agents and treatments affecting the vascular bed. One such agent is histamine, and the response to PTX, as measured by hypersensitivity following vasoactive amine challenge, is genetically controlled by the Bphs locus. Susceptibility to the induction of both experimental allergic encephalomyelitis (EAE) and experimental allergic orchitis (EAO) in mice is associated with, and in the latter case linked to, a susceptible allele at this locus. We report here the mapping of the Bphs locus to mouse chromosome 6, telomeric of Tcrb and centromeric of Prp (D6Nds8). This region also contains a number of loci of immunologic relevance including Igk, Ly-2, Ly-3, Il-5r, Ly-35, Ly-4, and Tnfr-2.

Original publication

DOI

10.1073/pnas.90.8.3700

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

15/04/1993

Volume

90

Pages

3700 - 3704

Keywords

Animals, Autoimmune Diseases, Base Sequence, Bordetella pertussis, Chromosome Mapping, Crosses, Genetic, DNA, Disease Susceptibility, Female, Genetic Linkage, Genetic Markers, Genetic Predisposition to Disease, Histamine, Liver, Male, Mice, Mice, Inbred C3H, Mice, Inbred CBA, Mice, Inbred Strains, Molecular Sequence Data, Oligodeoxyribonucleotides, Pertussis Toxin, Polymerase Chain Reaction, Receptors, Antigen, T-Cell, alpha-beta, Virulence Factors, Bordetella