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A number of CD4+ T cell lines were compared for their ability to act as target cells for human immunodeficiency virus (HIV) infection in syncytium- and plaque-forming assays. MT-4 and C8166 cells were the most sensitive indicator cells for HIV- and simian immunodeficiency virus (SIV)-induced cytopathic effects, and gave rise to macroscopic (MT-4) and microscopic (C8166) plaques. The MT-4 plaque assay was evaluated for the measurement of HIV- and SIV-neutralizing antibodies.

Original publication

DOI

10.1099/0022-1317-70-12-3327

Type

Journal article

Journal

J Gen Virol

Publication Date

12/1989

Volume

70 ( Pt 12)

Pages

3327 - 3333

Keywords

Animals, Antibodies, Viral, CD4-Positive T-Lymphocytes, Cell Line, Cytopathogenic Effect, Viral, HIV, HIV Antibodies, Humans, Immune Sera, Neutralization Tests, Simian Immunodeficiency Virus, Viral Plaque Assay