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We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-5 delta32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 delta32 heterozygotes within the cohort compared with a control population of blood donors was observed. An association between progression rate and CCR-5 delta32 heterozygosity was observed. Furthermore, analysis of proviral DNA V3 sequences from a subset of the cohort predicted that the majority of individuals (39 of 44) were infected with viruses predicted to utilize the beta-chemokine receptor CCR-5. The marked association between CCR-5 genotype and disease progression observed in this study may be a consequence of the predicted low frequency of CXCR-4-utilizing viruses present within the selected cohort.

Original publication

DOI

10.1089/aid.1998.14.1229

Type

Journal article

Journal

AIDS Res Hum Retroviruses

Publication Date

20/09/1998

Volume

14

Pages

1229 - 1234

Keywords

Alleles, Amino Acid Sequence, Chemokines, Cohort Studies, Consensus Sequence, Disease Progression, HIV Antibodies, HIV Envelope Protein gp120, HIV Envelope Protein gp160, HIV Infections, HIV Long-Term Survivors, HIV-1, Heterozygote, Humans, Molecular Sequence Data, Peptide Fragments, Receptors, CCR5, Time Factors