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OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced blaOXA-163 plasmid and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71-kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with interspecies/interlineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.

Original publication

DOI

10.1128/AAC.01130-16

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

11/2016

Volume

60

Pages

6948 - 6951

Keywords

Drug Resistance, Bacterial, Escherichia coli, Escherichia coli Proteins, Microbial Sensitivity Tests, Plasmids, beta-Lactamases