Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts.

Original publication

DOI

10.1038/ng.3583

Type

Journal article

Journal

Nat Genet

Volume

48

Pages

817 - 820

Keywords

Algorithms, Biological Specimen Banks, Cohort Studies, Computational Biology, Datasets as Topic, European Continental Ancestry Group, Genetics, Population, Genome, Human, Genomics, Haplotypes, High-Throughput Nucleotide Sequencing, Humans, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, United Kingdom