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The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts.

Original publication

DOI

10.1038/ng.3583

Type

Journal article

Journal

Nat Genet

Volume

48

Pages

817 - 820

Keywords

Algorithms, Biological Specimen Banks, Cohort Studies, Computational Biology, Datasets as Topic, European Continental Ancestry Group, Genetics, Population, Genome, Human, Genomics, Haplotypes, High-Throughput Nucleotide Sequencing, Humans, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, United Kingdom