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Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. We determined frequencies of active infection among dogs and other mammals in the United Kingdom. Samples from dogs (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening of 362 samples from cats, horses, donkeys, rodents, and pigs identified 3 (2%) positive samples from 142 horses. These samples were genetically divergent from CHV and nonprimate hepaciviruses that horses were infected with during 2012 in New York state, USA. Investigation of infected horses demonstrated nonprimate hepacivirus persistence, high viral loads in plasma (10(5)-10(7) RNA copies/mL), and liver function test results usually within reference ranges, although several values ranged from high normal to mildly elevated. Disease associations and host range of nonprimate hepaciviruses warrant further investigation.

Original publication

DOI

10.3201/eid1812.120498

Type

Journal article

Journal

Emerg Infect Dis

Publication Date

12/2012

Volume

18

Pages

1976 - 1982

Keywords

5' Untranslated Regions, Animals, Cats, Dogs, Hepacivirus, Hepatitis C, Horse Diseases, Horses, Humans, Mice, Molecular Sequence Data, Phylogeny, RNA, Viral, Swine, Viral Load, Viral Nonstructural Proteins