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Decades of research have shown that mutations in the p53 stress response pathway affect the incidence of diverse cancers more than mutations in other pathways. However, most evidence is limited to somatic mutations and rare inherited mutations. Using newly abundant genomic data, we demonstrate that commonly inherited genetic variants in the p53 pathway also affect the incidence of a broad range of cancers more than variants in other pathways. The cancer-associated single nucleotide polymorphisms (SNPs) of the p53 pathway have strikingly similar genetic characteristics to well-studied p53 pathway cancer-causing somatic mutations. Our results enable insights into p53-mediated tumour suppression in humans and into p53 pathway-based cancer surveillance and treatment strategies.

Original publication

DOI

10.1038/nrc.2016.15

Type

Journal article

Journal

Nat Rev Cancer

Publication Date

04/2016

Volume

16

Pages

251 - 265

Keywords

Genetic Predisposition to Disease, Genome, Human, Humans, Mutation, Neoplasms, Polymorphism, Single Nucleotide, Tumor Suppressor Protein p53