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Upon exposure to IFN-gamma, the standard proteasome is replaced by the immunoproteasome, which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing antigenic peptides presented to CD8(+) T cells. This view has been challenged this year by reports showing that some epitopes, mainly of self origin, are not processed by the immunoproteasome and that mature dendritic cells constitutively express immunoproteasomes and therefore cannot efficiently present such epitopes.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

04/2001

Volume

13

Pages

147 - 153

Keywords

Amino Acid Sequence, Animals, Antigen Presentation, Antigens, Neoplasm, Cysteine Endopeptidases, Epitopes, T-Lymphocyte, Gene Expression Profiling, Humans, Molecular Sequence Data, Multienzyme Complexes, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Proteins