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In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.

Original publication

DOI

10.4049/jimmunol.1000134

Type

Journal article

Journal

J Immunol

Publication Date

01/11/2010

Volume

185

Pages

5048 - 5055

Keywords

Adoptive Transfer, Animals, Antigens, Neoplasm, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Cross Reactions, Mice, Mice, Inbred BALB C, Neoplasms, Experimental, T-Lymphocytes, Regulatory