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Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found.

Original publication

DOI

10.1128/AAC.01459-07

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

07/2008

Volume

52

Pages

2657 - 2659

Keywords

Animals, Antimalarials, Base Sequence, DNA Primers, DNA, Protozoan, Drug Resistance, Multiple, Gene Amplification, Gene Dosage, Genes, MDR, Genes, Protozoan, Humans, Laos, Malaria, Vivax, Myanmar, Plasmodium vivax, Thailand