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Idiopathic bronchiectasis is a disease of chronic, bacterial lung infection, unresolving inflammation and progressive lung damage. Bronchiectasis can be associated with autoimmune diseases including ulcerative colitis. Defects of both innate and adaptive immunity have been proposed. The airway inflammation is characterized by interleukin-8 (IL-8) expression and infiltration by neutrophils and T cells. Here we investigated two candidate gene polymorphisms that may contribute to disease susceptibility: a CXCR-1 (+2607 G/C) gene polymorphism that is implicated in IL-8 binding and neutrophil trafficking as well as the interferon-gamma (IFNgamma) (+874 T/A) polymorphism which is linked to levels of IFNgamma production. These polymorphisms were distributed similarly in the idiopathic bronchiectasis group and controls, suggesting that these two candidate gene polymorphisms are not associated with disease susceptibility.

Original publication

DOI

10.1111/j.1399-0039.2006.00670.x

Type

Journal article

Journal

Tissue Antigens

Publication Date

10/2006

Volume

68

Pages

325 - 330

Keywords

Alleles, Bronchiectasis, Colitis, Ulcerative, Female, Genetic Predisposition to Disease, Genotype, Humans, Interferon-gamma, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Interleukin-8A