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This study sought to monitor the presence of carbapenem-resistant Enterobacteriaceae (CRE) and the proportion New Delhi metallo-beta-lactamase 1 (NDM-1)-producing bacteria between August 2010 and December 2012 in a surgical hospital in Vietnam. We identified 47 CRE strains from a total of 4,096 Enterobacteriaceae isolates (1.1 %) that were NDM-1-positive from 45 patients admitted to 11 different departments, with the majority being from the urology department. The NDM-1 gene was found in seven different species. Genotyping revealed limited clonality of NDM-1-positive isolates. Most of the isolates carried the NDM-1 gene on a plasmid and 17.8 % (8/45) of those were readily transferable. We found five patients at admission and one patient at discharge with NDM-1-positive bacteria in their stool. From 200 screening environmental hospital samples, five were confirmed to be NDM-1-positive and included Acinetobacter species (n = 3) and Enterobacter aerogenes (n = 2). The results reveal that NDM-1-producing Enterobacteriaceae are commonly isolated in patients admitted to a Vietnamese surgical hospital and are also detected in the hospital environment.

Original publication

DOI

10.1007/s10096-015-2345-6

Type

Journal article

Journal

Eur J Clin Microbiol Infect Dis

Publication Date

06/2015

Volume

34

Pages

1247 - 1254

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Enterobacteriaceae, Enterobacteriaceae Infections, Environmental Microbiology, Feces, Female, Genotype, Hospitals, Humans, Male, Middle Aged, Molecular Typing, Plasmids, Vietnam, Young Adult, beta-Lactamases