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The present study is an investigation of the safety and immunogenicity of DNA and modified vaccinia virus Ankara (MVA) candidate vaccines, each encoding the malaria DNA sequence multiple epitope-thrombospondin related adhesion protein (ME-TRAP), against Plasmodium falciparum. DNA ME-TRAP and MVA ME-TRAP are safe and immunogenic for effector and memory T cell induction. MVA ME-TRAP, with or without prior DNA ME-TRAP immunization, was more immunogenic and more cross-reactive in malaria-exposed individuals than in malaria-naive individuals, a finding suggesting that recombinant MVA vaccines are particularly promising for the development of a malaria vaccine for exposed populations. Both CD4(+) and CD8(+) T cells were induced by these vaccines.

Original publication

DOI

10.1086/378515

Type

Conference paper

Publication Date

15/10/2003

Volume

188

Pages

1239 - 1244

Keywords

Adult, Africa, Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Humans, Immunization Schedule, Lymphocyte Activation, Malaria Vaccines, Malaria, Falciparum, Plasmodium falciparum, Protozoan Proteins, Vaccines, DNA, Vaccinia virus