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BACKGROUND: Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes. METHODS: We conducted a retrospective case-note review of pregnancies during 2003-2013 using respiratory and obstetric records. RESULTS: We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis. CONCLUSION: Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.

Original publication

DOI

10.1177/1753495X15575628

Type

Journal article

Journal

Obstet Med

Publication Date

06/2015

Volume

8

Pages

99 - 101

Keywords

High-risk pregnancy, complications, maternal-fetal medicine, perinatal medicine, thoracic medicine