Molecular Markers andIn VitroSusceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
Gaillard T., Sriprawat K., Briolant S., Wangsing C., Wurtz N., Baragatti M., Lavina M., Pascual A., Nosten F., Pradines B.
ABSTRACTDeterminations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of thePlasmodium falciparumtetQ(pftetQ) gene (P= 0.11) orpfmdtgene (P= 0.87) or the number of PfTetQ KYNNNN repeats (P= 0.72).