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Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).

Original publication

DOI

10.1128/AAC.00345-15

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

08/2015

Volume

59

Pages

5080 - 5083

Keywords

Antimalarials, Artemisinins, Doxycycline, Drug Resistance, Gene Dosage, Genetic Markers, Humans, Malaria, Falciparum, Parasitic Sensitivity Tests, Plasmodium falciparum, Thailand