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© Cambridge University Press 2007 and Cambridge University Press, 2009. Introduction The study of the host genetic component of infectious disease is potentially one of the most difficult areas of complex human genetic disease analysis for one major reason: the absolute requirement for a host-pathogen interaction to cause disease. Since the pathogen has its own genome, with all of its attendant potential for variability, there has been an ongoing “arms race” between man and microbe that has driven each to incorporate changes within their genomes that increase their survival chances should they encounter the other. However, this strong evolutionary pressure on the human genome has also inevitably produced associations between gene variants and disease. The field of genetic susceptibility to infectious disease has been around for over 50 years now and there is a substantial body of evidence for the role of genetics in infectious disease susceptibility. Historical perspective Infectious disease is as old as humanity and remains a significant influence on polymorphism in the human genome. Major effects of infectious disease such as epidemics that have drastically reduced populations to a small percentage of individuals, so-called “bottlenecks,” such as the Black Death in Europe and the introduction of smallpox and other diseases to the Americas, have a strong selective effect. In addition, the slow continual onslaught of endemic diseases that are still with us today, such as malaria, tuberculosis and, more recently, AIDS, lead to a continual enrichment within the population for resistance alleles, even when these might be harmful and would be quickly lost in the absence of disease.

Original publication

DOI

10.1017/CBO9780511543555.020

Type

Chapter

Book title

Genes and Common Diseases

Publication Date

01/01/2007

Volume

9780521833394

Pages

277 - 301