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The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P = 0.04). The high frequency of Pfmspdbl2 codon 591S in Kenya may be driven by the widespread use of lumefantrine in artemisinin combination therapy (Coartem).

Original publication

DOI

10.1128/AAC.03522-14

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

03/2015

Volume

59

Pages

1770 - 1775

Keywords

Antimalarials, Artemether, Lumefantrine Drug Combination, Artemisinins, Codon, Drug Combinations, Drug Resistance, Ethanolamines, Fluorenes, Humans, Kenya, Lumefantrine, Malaria, Falciparum, Plasmodium falciparum, Polymorphism, Genetic, Protozoan Proteins