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The evolutionarily conserved T-box family of transcription factors have critical and well-established roles in embryonic development. More recently, T-box factors have also gained increasing prominence in the field of cancer biology where a wide range of cancers exhibit deregulated expression of T-box factors that possess tumour suppressor and/or tumour promoter functions. Of these the best characterised is TBX2, whose expression is upregulated in cancers including breast, pancreatic, ovarian, liver, endometrial adenocarcinoma, glioblastomas, gastric, uterine cervical and melanoma. Understanding the role and regulation of TBX2, as well as other T-box factors, in contributing directly to tumour progression, and especially in suppression of senescence and control of invasiveness suggests that targeting TBX2 expression or function alone or in combination with currently available chemotherapeutic agents may represent a therapeutic strategy for cancer.

Original publication

DOI

10.1016/j.bbcan.2014.08.004

Type

Journal article

Journal

Biochim Biophys Acta

Publication Date

12/2014

Volume

1846

Pages

380 - 391

Keywords

Cancer, Cancer therapy, T-box factors, TBX2, Transcription factors, Animals, DNA Damage, Humans, Neoplasms, Signal Transduction, T-Box Domain Proteins