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RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.

Original publication

DOI

10.1007/s13238-014-0076-6

Type

Journal article

Journal

Protein Cell

Publication Date

11/2014

Volume

5

Pages

805 - 815

Keywords

Animals, Genetic Predisposition to Disease, Humans, Molecular Targeted Therapy, Neoplasms, RNA Interference, Viral Proteins, Virus Diseases