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Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

Original publication

DOI

10.1128/JVI.01662-14

Type

Journal article

Journal

J Virol

Publication Date

01/09/2014

Volume

88

Pages

10244 - 10251

Keywords

Glucans, Glycomics, Glycoproteins, Humans, Uukuniemi virus, Viral Proteins, Virion, Virus Assembly, Virus Release