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The major barrier to effective cancer therapy is the presence of genetic and phenotypic heterogeneity within cancer cell populations that provides a reservoir of therapeutically resistant cells. As the degree of heterogeneity present within tumours will be proportional to tumour burden, the development of rapid, robust, accurate and sensitive biomarkers for cancer progression that could detect clinically occult disease before substantial heterogeneity develops would provide a major therapeutic benefit. Here, we explore the application of chromatin conformation capture technology to generate a diagnostic epigenetic barcode for melanoma. The results indicate that binary states from chromatin conformations at 15 loci within five genes can be used to provide rapid, non-invasive multivariate test for the presence of melanoma using as little as 200 μl of patient blood.

Original publication

DOI

10.1111/pcmr.12258

Type

Journal article

Journal

Pigment Cell Melanoma Res

Publication Date

09/2014

Volume

27

Pages

788 - 800

Keywords

biomarker, chromatin conformation capture, epigentic, melanoma, Adult, Aged, Algorithms, Biomarkers, Tumor, Cell Line, Tumor, Chromatin, Computational Biology, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Genetic Markers, Humans, Male, Melanoma, Microphthalmia-Associated Transcription Factor, Middle Aged, Multivariate Analysis, Reproducibility of Results, Skin Neoplasms