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Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.

Original publication

DOI

10.1097/INF.0000000000000143

Type

Journal article

Journal

Pediatr Infect Dis J

Publication Date

05/2014

Volume

33

Pages

495 - 498

Keywords

Anti-HIV Agents, Area Under Curve, Body Weight, Child, Child, Preschool, Cross-Over Studies, Female, Guidelines as Topic, HIV Infections, Hemoglobins, Humans, Infant, Male, Plasma, Uganda, World Health Organization, Zidovudine