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Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.

Original publication

DOI

10.4269/ajtmh.13-0706

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

04/2014

Volume

90

Pages

609 - 611

Keywords

Adult, Antibodies, Protozoan, Antimalarials, Female, Humans, Hypersplenism, Immunoglobulin M, Malaria, Mefloquine, Plasmodium, Pregnancy, Pregnancy Complications, Parasitic, Retrospective Studies, Splenomegaly