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UNLABELLED: SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection. AVAILABILITY: http://www.stats.ox.ac.uk/mathgen/software.html. SUPPLEMENTARY INFORMATION: http://www.stats.ox.ac.uk/mathgen/software.html.

Original publication

DOI

10.1093/bioinformatics/bth417

Type

Journal article

Journal

Bioinformatics

Publication Date

12/12/2004

Volume

20

Pages

3673 - 3675

Keywords

Animals, Biological Evolution, Computer Simulation, Genetic Variation, Genetics, Population, Humans, Models, Genetic, Models, Statistical, Recombination, Genetic, Selection, Genetic, Software